No information is available on the relationship of age to the effects of phenytoin in geriatric patients. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients taking phenytoin. Cisatracurium, pancuronium, rocuronium and vecuronium: resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents has occurred in patients chronically administered phenytoin. Whether or not phenytoin has the same effect on other non-depolarizing agents is unknown. High blood sugar hyperglycemia. how to piracetam
You should not use phenytoin if you also take delavirdine Rescriptor or if you are allergic to phenytoin, ethotoin Peganone fosphenytoin Cerebyx or mephenytoin Mesantoin. F; see USP controlled room temperature. Colesevelam: May decrease the serum concentration of Phenytoin. Management: Administer phenytoin at least 4 hours prior to colesevelam. If you are taking phenytoin to treat seizures, do not stop using phenytoin suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. It also makes vaginal fluid thicker to help prevent from reaching an egg fertilization and changes the lining of the uterus womb to prevent attachment of a fertilized egg. If a fertilized egg does not attach to the uterus, it passes out of the body.
You have a decreased appetite. Pimavanserin: CYP3A4 Inducers Strong may decrease the serum concentration of Pimavanserin. Dilantin is a prescription medicine used to treat certain types of seizures called tonic-clonic grand mal and psychomotor temporal lobe seizures.
Maraviroc: CYP3A4 Inducers Strong may decrease the serum concentration of Maraviroc. Management: Increase maraviroc adult dose to 600 mg twice daily when used with strong CYP3A4 inducers. This does not apply to patients also receiving strong CYP3A4 inhibitors. In all cases of lymphadenopathy, follow-up observation for an extended period is indicated and every effort should be made to achieve seizure control using alternative antiepileptic drugs. Administration of phenytoin to pregnant animals resulted in teratogenicity increased incidences of fetal malformations and other developmental toxicity including embryofetal death, growth impairment, and behavioral abnormalities in multiple animal species at clinically relevant doses.
Softening of your bones osteopenia, osteoporosis, and osteomalacia. This can cause broken bones. Tell your doctor if you just had or will be having surgery or if you will be confined to a bed or chair for a long time such as a long plane flight. Are pregnant or plan to become pregnant. Dilantin may harm your unborn baby. Do not change brands or dosage forms of phenytoin without first checking with your doctor. Different products may not work the same way. If you refill your medicine and it looks different, check with your pharmacist. Tripathi YB and Chaurasia S. Interaction of Strychnos nux-vomica-products and iron: with reference to lipid peroxidation. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Flunitrazepam: CNS Depressants may enhance the CNS depressant effect of Flunitrazepam. Bedaquiline: CYP3A4 Inducers Strong may decrease the serum concentration of Bedaquiline.
CloZAPine: CYP3A4 Inducers Strong may decrease the serum concentration of CloZAPine. In most cases where interactions were seen, the effect is a decrease in phenytoin levels when the drugs are taken at the same time. When possible, phenytoin and these products should not be taken at the same time of day. CAPSULES without first talking to a healthcare provider. Paraldehyde: CNS Depressants may enhance the CNS depressant effect of Paraldehyde. This medicine is a light blue, oblong capsule imprinted with "432" and "432". Serious and sometimes fatal skin reactions have been reported with phenytoin suspension. Do not stop taking phenytoin without first talking to your healthcare provider. Ribociclib: CYP3A4 Inducers Strong may decrease the serum concentration of Ribociclib. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. If your doctor prescribes these medicines together, you may need to have your bleeding times and your blood levels of your anticonvulsant checked more often, especially when first starting to take them together. If you have any signs of bleeding such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools or if you have blurred vision, unsteadiness, nausea, or confusion, contact your doctor right away. If you are receiving liquid feedings enteral feedings the feedings should be stopped one to two hours before you take phenytoin. The feedings may be restarted one to two hours after the phenytoin dose. Chloramphenicol: Phenytoin may decrease the serum concentration of Chloramphenicol. Phenytoin may increase the serum concentration of Chloramphenicol. Chloramphenicol may increase the serum concentration of Phenytoin. ABCB1 Inducers may decrease the serum concentration of Sofosbuvir. Swallow the tablet whole or chew it thoroughly before being swallowed together with a glass of water. ursofalk
Do not stop taking Dilantin without first talking to your healthcare provider. Stopping Dilantin suddenly can cause serious problems. Many other prescription and nonprescription medicines eg, used for allergic reactions, asthma or other breathing problems, blood thinning, diabetes, infections, inflammation, aches and pains, attention deficit hyperactivity disorder, alcoholism, cancer, high blood pressure, indigestion, irregular heartbeat or other heart problems, hepatitis C, high blood iron levels, high cholesterol, HIV, birth control, hormone replacement, immune system suppression, mental or mood problems, pain, sleep, seizures, stomach or bowel problems multivitamin products, and herbal or dietary supplements eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort may interact with phenytoin suspension. Phenytoin can cause overgrowth of your gums. Brushing and flossing your teeth and seeing a dentist regularly while taking phenytoin can help prevent this from happening. ABCB1 Inducers may decrease the serum concentration of Dabigatran Etexilate. Management: Avoid concurrent use of dabigatran with p-glycoprotein inducers when possible. Isolated cases of malignancies including neuroblastoma and coagulation defects in the neonate may be life threatening following delivery have also been reported. Maternal use of phenytoin should be avoided when possible to decrease the risk of cleft palate and poor cognitive outcomes. Polytherapy may also increase the risk of congenital malformations; monotherapy is recommended Harden and Meader 2009. The maternal use of folic acid throughout pregnancy is recommended to reduce the risk of major congenital malformations Harden and Pennell 2009. Potentially life-threatening bleeding disorders in the newborn may also occur due to decreased concentrations of vitamin K-dependent clotting factors following phenytoin exposure in utero; vitamin K administration to the mother prior to delivery and the newborn after birth is recommended. HLA B gene, in patients using carbamazepine. Nelfinavir: May decrease the serum concentration of Phenytoin. Phenytoin may decrease the serum concentration of Nelfinavir. cost of using domperidone domperidone
Vesicant; ensure proper needle or catheter placement prior to and during IV infusion. Avoid extravasation. Status epilepticus injection only: Treatment of generalized tonic-clonic status epilepticus. Discuss any questions or concerns with your doctor. Check your blood or urine glucose level frequently, as directed by your doctor. Promptly report any abnormal results as directed. Johnston, G. A. The specificity of strychnine as a glycine antagonist in the mammalian spinal cord. Dilantin can cause overgrowth of your gums. Brushing and flossing your teeth and seeing a dentist regularly while taking Dilantin can help prevent this from happening. St. John's Wort, theophylline, and vigabatrin. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment. What is the most important information I should know about phenytoin Dilantin? buy truvada quick delivery
Do not drive, operate heavy machinery, or do other dangerous activities until you know how phenytoin affects you. Phenytoin can slow your thinking and motor skills. Injection may contain sodium. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see section. If any of these effects persist or worsen, notify your doctor or promptly. Read the Patient Information Leaflet provided by your before you start using this product and each time you get a refill. The leaflet contains very important information on when to take your pills and what to if you miss a dose. If you have any questions, ask your doctor or pharmacist. If you or your child notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor. Gestrinone: Fosphenytoin-Phenytoin may decrease the serum concentration of Gestrinone. Adams BD, Buckley NH, Kim JY, Tipps LB. Fosphenytoin may cause hemodynamically unstable bradydysrhythmias. J Emerg Med. 2006 Jan. Phenytoin may also be used for purposes not listed in this medication guide. Antifungal Agents Azole Derivatives, Systemic: May increase the serum concentration of Phenytoin. Applicable Isavuconazonium considerations are addressed in separate monographs. Phenytoin may decrease the serum concentration of Antifungal Agents Azole Derivatives, Systemic. Management: Concomitant therapy with itraconazole, voriconazole, or ketoconazole and phenytoin should probably be avoided, as antifungal failure is likely. Consider selecting alternative antifungal therapy. Exceptions: Isavuconazonium Sulfate. Inactive ingredients: lactose monohydrate, confectioner's sugar, talc, and magnesium stearate. Lab tests, including blood phenytoin levels or liver function, may be performed while you use phenytoin suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Dolgin JG, Nix DE, Sanchez J, Watson WA. Pharmacokinetic simulation of the effect of multiple-dose activated charcoal in phenytoin poisoning--report of two pediatric cases. DICP. 1991 Jun. Parrilli, M. Polysaccharides from seeds of Strychnos species.
The incidences of hepatocellular tumors were increased in female mice at all but the lowest dose tested. No increases in tumor incidence were observed in rats. Phenytoin can make birth control pills less effective. Ask your doctor about using non hormonal birth control condom, diaphragm with spermicide to prevent pregnancy while taking phenytoin. This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. Foods and beverages high in tyramine should be avoided while you are taking this medication and for at least 2 weeks after you stop using this medication. Sonidegib: CYP3A4 Inducers Strong may decrease the serum concentration of Sonidegib. In adults, if seizure control is established with divided doses of three 100-mg DILANTIN extended phenytoin sodium capsules, USP daily, once-a-day dosage with 300 mg of DILANTIN extended phenytoin sodium capsules, USP may be considered. Studies comparing divided doses of 300 mg with a single daily dose of this quantity indicated absorption, peak serum levels, biologic half-life, difference between peak and minimum values, and urinary recovery were equivalent. Once-a-day dosage offers a convenience to the individual patient or to nursing personnel for institutionalized patients and is intended to be used only for patients requiring this amount of drug daily. A major problem in motivating noncompliant patients may also be lessened when the patient can take this drug once a day. However, patients should be cautioned not to miss a dose, inadvertently. Mirodenafil: CYP3A4 Inducers Strong may decrease the serum concentration of Mirodenafil. Management: Consider avoiding the concomitant use of mirodenafil and strong CYP3A4 inducers. If combined, monitor for decreased mirodenafil effects. Mirodenafil dose increases may be required to achieve desired effects. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS also known as Multiorgan hypersensitivity, has been reported in patients taking antiepileptic drugs, including Dilantin. Some of these events have been fatal or life-threatening. Analgesics Opioid: CNS Depressants may enhance the CNS depressant effect of Analgesics Opioid. Management: Avoid concomitant use of opioid analgesics and benzodiazepines or other CNS depressants when possible. These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Digestive System: Acute hepatic failure, toxic hepatitis, liver damage, nausea, vomiting, constipation, enlargement of the lips, and gingival hyperplasia. To be sure this medication is helping your condition, your blood may need to be tested often. You may also need a blood test when switching from one form of phenytoin to another. Visit your doctor regularly. Dilantin may cause fetal harm when administered to a pregnant woman. tizanidine generic price at walmart
Tofacitinib: CYP3A4 Inducers Strong may decrease the serum concentration of Tofacitinib. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Mowry JB, Spyker DA, Brooks DE, Zimmerman A, Schauben JL. 2015 Annual Report of the American Association of Poison Control Centers' National Poison Data System NPDS: 33rd Annual Report. Clin Toxicol Phila. 2016 Dec. Etizolam: CYP3A4 Inducers Strong may decrease the serum concentration of Etizolam. It is very important that your doctor check your progress at regular visits while you or your child are using phenytoin to see if it is working properly and to allow for a change in the dose. Blood tests may be needed to check for any unwanted effects. Are breast feeding or plan to breastfeed. Phenytoin can pass into breast milk. You and your healthcare provider should decide if you will take phenytoin while you are breastfeeding. If you or your child have any questions about this ask your doctor. Teniposide: Phenytoin may decrease the serum concentration of Teniposide. Management: Consider alternatives to combined treatment with phenytoin and teniposide due to the potential for decreased teniposide concentrations. If the combination cannot be avoided, monitor teniposide response closely. Intravenous administration should not exceed 50 mg per minute in adults. IM: Ordinarily, this drug should not be given IM because of the risk of necrosis, abscess formation, and erratic absorption. If IM administration is required, compensating dosage adjustments are necessary to maintain therapeutic plasma levels. An IM dose 50% greater than the oral dose is necessary to maintain these levels. When returned to oral administration, the dose should be reduced by 50% of the original oral dose for 1 week to prevent excessive plasma levels due to sustained release from IM tissue sites. bema.info dilantin
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Amphetamines: May decrease the serum concentration of Phenytoin. Immediate release: Divide daily dose into 2 to 3 doses per day; if the daily dosage cannot be divided equally, take the larger dose before retiring. Careful cardiac monitoring is needed during and after IV administration of this drug. What should I avoid while taking phenytoin Dilantin? DRESS see have been observed. altace
RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Temsirolimus: Phenytoin may decrease the serum concentration of Temsirolimus. Concentrations of the active metabolite, sirolimus, are also likely to be decreased and maybe to an even greater degree. feldene
It is not known whether this drug passes into milk. Consult your doctor before -feeding. Contraceptives Progestins: Phenytoin may diminish the therapeutic effect of Contraceptives Progestins. Contraceptive failure is possible. Management: Contraceptive failure is possible. Use of an alternative, nonhormonal contraceptive is recommended. Dose is based on age and body weight and must be determined by your doctor. At first, 5 milligrams mg per kilogram kg of body weight given in two or three divided doses per day. Your doctor may adjust your dose as needed. Ask your health care provider any questions you may have about how to use phenytoin suspension. buy or cozaar
Velpatasvir: CYP2C8 Inducers Strong may decrease the serum concentration of Velpatasvir. It is very important to continue taking this medication exactly as prescribed by your doctor. Your abdomen is bloated. CYP3A4 inducers with roflumilast. The Canadian product monograph makes no such recommendation but notes that such agents may reduce roflumilast therapeutic effects. This may not be a complete list of all interactions that may occur. Ask your health care provider if phenytoin suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.